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Electrolytic properties of hyaluronan solutions
Suchá, Šárka ; Smilek, Jiří (referee) ; Chytil, Martin (advisor)
This batchelor thesis deals with electrolytic properties of hyaluronan in aqueous solutions. In this study measuring of conductance, acid-base and conductrometric titration, and UV-VIS spectroscopy were used. The measuring of conductance was made on the solutions of different concentrations of hyaluronic acid and of different ionic strength. Acid-base titrations were performed in water solution and conductometric titrations were performed in 0,3mmol.dm–3 solution of sodium chloride. UV-VIS spectra of hyaluronic acid were measured in solution with addition of acid, base and in buffer solution. Values of pKa obtained from the above mentioned measurements was between 2,8–6,5.
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Algoritmy pro řezy v grafech
Pecsők, Ján ; Kolman, Petr (advisor) ; Tiwary, Hans Raj (referee)
Graph-partitioning problems can be generically defined as a family of problems in which we are asked to partition a graph into two or more components. We present overview of methods and concepts used to find best graph partitions according to several criteria. We prove duality of multi-commodity flow and sparsest cut problem due to work of Leighton and Rao by describing algorithm using a Linear programming relaxation and a geometric embedding. Then we present the work of Arora, Rao and Vazirani (ARV) and their algorithm based on Semidefinite programming relaxation and a geometric embedding. We also explain the concept of expander flows first introduced in the work of ARV. One section of our work is devoted to the spectral graph theory, introducing the concepts of the spectral gap, random walks, conductance and relations between them. We connect the ideas of expander flows and spectral theory in chapter about so called Cut-Matching game framework. Finally we present the performance results of our implementation of the Leighton-Rao and the Cut-Matching game algorithms. Powered by TCPDF (www.tcpdf.org)
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Charge Transport through Molecular Towers Based on Tetraphenyhmethane Tripods
Kolivoška, Viliam ; Šebera, Jakub ; Lindner, M. ; Valášek, M. ; Mayor, M. ; Mészáros, G. ; Gasior, Jindřich ; Hromadová, Magdaléna
Molecular platforms with multiple anchors were introduced recently to provide robusi coupling between molecular electronic components and metallic electrodes. In this work, charge transport in tower-shaped single molecule conductors based on tetraphenylmethane tripod possessing three thiol anchors is investigated by scanning tunneling microscopy break junction technique. The effect of tripod substitution pattern and number of repeating units in molecule is addressed. The substitution was found to influence conductance value in early stages of molecular junction evolution, where tower lays parallel to surface. In late stages, the charge is transported through principal molecular axis and junction breaks thermally in tilted configuration.
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Algoritmy pro řezy v grafech
Pecsők, Ján ; Kolman, Petr (advisor) ; Tiwary, Hans Raj (referee)
Graph-partitioning problems can be generically defined as a family of problems in which we are asked to partition a graph into two or more components. We present overview of methods and concepts used to find best graph partitions according to several criteria. We prove duality of multi-commodity flow and sparsest cut problem due to work of Leighton and Rao by describing algorithm using a Linear programming relaxation and a geometric embedding. Then we present the work of Arora, Rao and Vazirani (ARV) and their algorithm based on Semidefinite programming relaxation and a geometric embedding. We also explain the concept of expander flows first introduced in the work of ARV. One section of our work is devoted to the spectral graph theory, introducing the concepts of the spectral gap, random walks, conductance and relations between them. We connect the ideas of expander flows and spectral theory in chapter about so called Cut-Matching game framework. Finally we present the performance results of our implementation of the Leighton-Rao and the Cut-Matching game algorithms. Powered by TCPDF (www.tcpdf.org)
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Structure, function and pharmacology of NMDA receptors
Švehla, Pavel ; Vyklický, Ladislav (advisor) ; Bendová, Zdeňka (referee)
Glutamate is a major excitatory neurotransmitter between neurons in the central nervous system. The effect of glutamate is caused by the activation of distinct ionotropic glutamate channels: AMPA, kainate and NMDA receptors. NMDA receptors play a critical role in the synaptic plasticity and excitotoxicity. Despite the crucial role of these receptors in the right function of the brain, their overexcitation under pathological conditions may result in such neurological disorders as Alzheimers, Parkinsons and Huntingtons diseases. The aim of this work is to review available data concerning the molecular structure of NMDA subtype of ionotropic glutamate receptors, their pharmacology and therapeutic potential.
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Electrolytic properties of hyaluronan solutions
Suchá, Šárka ; Smilek, Jiří (referee) ; Chytil, Martin (advisor)
This batchelor thesis deals with electrolytic properties of hyaluronan in aqueous solutions. In this study measuring of conductance, acid-base and conductrometric titration, and UV-VIS spectroscopy were used. The measuring of conductance was made on the solutions of different concentrations of hyaluronic acid and of different ionic strength. Acid-base titrations were performed in water solution and conductometric titrations were performed in 0,3mmol.dm–3 solution of sodium chloride. UV-VIS spectra of hyaluronic acid were measured in solution with addition of acid, base and in buffer solution. Values of pKa obtained from the above mentioned measurements was between 2,8–6,5.
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